De Los Santos was born June 11, 1939 in Goliad to Domingo and Juanita (Salinas) Rodriguez. She married Lucio De Los Santos on June 27, 1959 in Charco.
She retired as custodian after 24 years with the Harlandale ISD and was co-owner of Needful Things Resale Shop.
She was preceded in death by her parents; her husband on Aug. 23, 2011; brothers, Juan Rodriguez and Ernesto Rodriguez; and sisters, Sylvia Torres, Felicita Rojas, Dolores Rodriguez and Josefa Garza.
Survivors include two sons, Ronnie (Lucy) De Los Santos and Rudy De Los Santos, both of San Antonio; two daughters, Rebecca De Los Santos of Pasadena, California, and Ruby (Willie) Ramirez of San Antonio; 13 grandchildren; 21 great-grandchildren; two brothers, Domingo Rodriguez and Hector (Chana) Rodriguez, both of Goliad; and three sisters, Margaret Rodriguez, Norma Flores and Santos (Herb) Ramzinsky, all of Goliad.
Visitation was from 11 a.m. to 9 p.m. July 23 at Angelus Funeral Home. A rosary was recited at 7 p.m.
A graveside service was conducted at 11 a.m. July 24 at the Runge Cemetery.