The Indians scored the first touchdown of the night in the first possession. George West answered right back with an 85-yard return for a touchdown by Bobby Torres on the ensuing kickoff.
Both squads traded touchdowns before the Horns took the lead right before halftime when Andrew Katzfey hit Joseph Fiest from 20 yards out for a 19-13 lead.
The Horns added two more scores in the second half, both rushing touchdowns by Torres and Hudson Wallace to make it 31-13, George West.
With the win, George West improves to 7-2 on the season, and 5-0 in District 15 play.
Next week, the Horns will take on Luling in a winner takes all for the district title.